House mice outcompeted their wild relatives to become domesticated as soon as long-term human settlements appeared, some 5000 years before agriculture took hold.
The advent of farming marks a huge change in human populations – a change in diet, social structure and a switch to a more sedentary lifestyle. Agriculture also had a profound impact on wild animals, and is thought to have led to the domestication of many species, from wolves to cattle and chickens. But other species became domesticated accidentally – as humans started storing grain for lengthy periods of time, the house mouse adapted to thrive in this new ecosystem. Now, a new study shows that it was our sedentary lifestyle, not agriculture, that domesticated one of our most prolific pests.