Recoding Genes: How Post-Transcriptional Editing is Giving Squid the Upper Hand

Natural selection is incredibly good at adapting organisms to their environment, even those environments that are harsh and difficult to live in. But the changes currently happening to the World’s climate, hydrology and land-use may be too rapid for natural selection to act, in most cases. For some species, natural selection has provided the tools to adapt more rapidly, through behavioural or physiological changes. A few species have gone further still, evolving the ability to edit their own genes as they are expressed. Recent research shows this ability is used rampantly by certain species of squid, which may explain why they have responded relatively well to human impacts on the environment so far.
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A New Language for Life

All the beautiful, remarkable complexities of life that we see around us are, believe it or not, encoded at the most basic level by an alphabet just 5 letters long. The DNA code, which is shared by all life on Earth, is formed from molecules known as nucleotides which come in just four forms: Adenine, Cytosine, Guanine and Thymine. RNA, the single-stranded cousin of DNA which is important in translating DNA into protein, adds a fifth letter – Uracil. It is truly one of the most impressive feats of evolution, that such a simple alphabet can generate such diversity and adaptation. However, recently scientists from The Scripps Research Institute, California have engineered a life form with an expanded vocabulary.

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